S u c c e s s
passion + hard work + collaboration + perseverance
Dr. Yang Xia, MD, PHD
Professor
The University of Texas Health Science Center at Houston
McGovern Medical School
Department of Biochemistry and Molecular Biology
Dr. Xia received MD in a prestigious six-year English-Medicine program in Xiangya Medical School in China in 1992 and PhD in Molecular Pathology in University of Texas Health Science Center-Graduate School of Biomedical Science in 1998. Dr. Xia received postdoctoral training in mouse genetics until 2001 and established her independent laboratory in 2001 in the Department of Biochemistry and Molecular Biology at the University of Texas-McGovern Medical School. Dr. Xia focuses on translational research of cardiovascular diseases including hypertension, preeclampsia, chronic kidney disease, blood disorders (sickle cell disease) and high altitude. Those projects are united by common features of hypoxia. Dr. Xia’s goal is to translate her discovery-driven basic science smoothly and quickly to the clinic to benefit human health. To accomplish this goal, Dr. Xia’s laboratory has conducted multiple non-biased screening (including metabolomic screening and gene array) to identify potential pathogenic markers for the diseases. Extending from the initial screens, Dr. Xia has conducted preclinical studies using both pharmacological and genetic approaches to determine the pathophysiological role of these newly identified molecules in animal models of specific diseases. Finally, Dr. Xia has conducted human translational research to determine whether these newly identified pathogenic biomarkers are diagnostic markers for early detection and therapeutic targets.
Dr. Xia has successfully led a highly interactive, collaborative and productive research team including both basic and clinical research scientists. Dr. Xia has been continuously funded since joining the BMB faculty and has received nearly $17 million in funding from multiple agencies, including NIDDK, NIHLB and AHA, among others. In addition to her outstanding track record in basic and translational research as a principal investigator, Dr. Xia brings her significant experience in the development of leading research and education programs in biomedical research and education. Dr. Xia orchestrated the establishment of a cooperative agreement between Central South University (CSU, a major Chinese university) and the University of Texas Health Science Center Houston (UTHSC). As Program Director, Dr. Xia has focused on an ongoing academic and educational relationship between UTHSC and faculty and students from CSU and its affiliated medical school and hospitals. She has trained numerous PhD and MD/PhD students, postdoctoral fellows, clinical residents and fellows (Hematology and ObGyn) and visiting faculty. As a result of her guidance these students, residents and fellows have received awards for their research including Dean’s Research Award, Harry and Isabel C. Cameron Fellowship, the prestigious inaugural UT System Jess Hay Chancellor’s Fellowship.
Dr. Xia served on a study section for the American Heart Association and served as a member of NIH study sections and special emphasis panels. Because of her research contribution in the area of sickle cell disease, Dr. Xia was appointed to the Sickle Cell Disease Advisory Committee of the National Heart, Lung and Blood Institute, NIH (SCDAC). Dr. Xia’s research has been recognized by numerous awards including Innovative Research Funds from AHA, A Challenge grant from NIH, McGovern Scholar, Excellence Award of Basic Research from Women Research Forum,Dean’s Teaching Excellence Award, Lyndon Baines Johnson Research Award from the AHA, Winner of Basic Cardiovascular Science Outstanding Early Career Development Award from the AHA, Finalist for the Young Investigator Award of International Society for Heart Research and Presidential Fellowship Award.
Accomplishments and Awards
NHLBI Advisory Committee on Sickle Cell Disease
American Hematology Society, Member, Abstract Reviewer and Meeting Moderator
American Heart Association, Fellow
National Society of Chinese Biomedical Scientist in America, Member
Texas-Society of Chinese Biomedical Scientist in America, Treasure and Advisory Board member
Lyndon Baines Johnson Research Award from the American Heart Association
Outstanding Early Career Development Award, American Heart Association
Dean’s Teaching Excellence Award, University of Texas Medical School at Houston
McGovern Scholar, University of Texas Medical School at Houston
Excellence Award for Basic Research, University of Texas Medical School at Houston
Research
The Xia Lab is a multi-faceted lab that focuses on collaboration, cutting-edge research, and using precise technologies to eradicate and understand diseases
Publications
Publications
Publications
Sphingosine 1 Phosphate Promotes Erythrocyte Glycolysis and Oxygen Release for Adaptation to High Altitude Hypoxia (Nat Commun. 2016)
Erythrocytes retain hypoxic adenosine response for faster acclimatization on re-ascent (Nat Commun. 2017)
Publications
Publications
Lab News
Recent lab news, activities, and awards
Recent and Notable Publications
Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase. (Am J Hypertens. 2017)
Current Lab Members
Professor
preeclampsia, sickle cell disease, chronic kidney disease, hypertension, hypoxia, high altitude, erythrocyte metabolic reprogramming and metabolomic profiling
Instructor
Hypoxic response in RBC, plasma adenosine regulation in hypoxia and sickle cell disease pathology, ubiquitin/proteasome signaling in RBC
Visiting Physician Scientist
perinatal medicine, especially in adenosine metabolism and preeclampsia
Dr. Xiudong Yang, PhD
Post-Doc, Lab Manager
adenosine and blood storage
COLLABORATORS
Links to their website and profile:
Previous Lab Members
Former PhD Candidate
Erythrocyte metabolomics, Sphingosine 1-phosphate, Sickle Cell Disease
Former PhD Candidate
Preeclampsia: The roles of acute inflammation and intrauterine stress
Dr. Weiru Zhang, MD, PhD
Former visiting scientist
AT1 Receptor role in preeclampsia and autoimmunity
Dr. Yinbo Dai PhD
Former visiting scientist
Adenosine signaling and chronic kidney disease
Dr. Takayuki Iriyama, MD, PhD
Former visiting scientist
Adenosine signaling and the pathogenesis of preeclampsia
Dr. Laura Hart, MD, PhD
Former fellow
Preeclampsia: The roles of acute inflammation and intrauterine stress
Dr. C. Zhou, MD, PhD
Former visiting scientist
Angiotensin receptors, autoimmunity, and preeclampsia
Dr. O. Ashimi, MD, PhD
Former fellow scientist
Adenosine signaling and the pathology of SCD
Dr. Hongyu Wu, MD, PhD
Former postdoctoral fellow
Adenosine signaling and the pathology of SCD
Dr. Jiaming Wen, PhD
Former visiting student
Adenosine signaling and the function of penile erection
Dr. Wei Wang, MD, PhD
Former visiting student
Secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia
Dr. Chen Ning, MD, PhD
Former visiting student
Adenosine signaling and the function of penile erection
Dr. Cheng Zhao, MD, PhD
Former visiting student
Adenosine signaling and the function of penile erection
Dr. Aji Huang, MD, PhD
Former visiting student
Adenosine signaling, Placental DNA Hypomethylation, A2B Receptor Signaling in Preeclampsia
Dr. Shushan Zhao, MD, PhD
Former visiting student
Adenosine signaling and the pathology of SCD
Dr. Renna Luo, MD, PhD
Former visiting student
Adenosine signaling and chronic kidney disease
Dr. Xia Hu, MD, PhD
Former visiting student
Adenosine signaling and pain
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