My interest in studying sickle cell disease (SCD) is due to my family health history. I have several family members both living and decease who are affected with SCD. One of the major complications of sickle cell disease is chronic pain. In fact, chronic pain in SCD is poorly understood. The Xia laboratory has investigated the role of adenosine and sphingosine-1-phosphate (S1P) signaling in erythrocytes and discovered that adenosine signaling has a detrimental function in SCD erythrocytes. My project focuses on extracellular S1P signaling and how this signaling mechanism promotes pain in SCD. As a graduate student in Dr. Xia’s lab, I will conduct this research. I have a motivation necessary to complete my training for a doctoral degree in a highly skilled translational research laboratory. I have a record of success from my previous research employment and a self-expectation for excellence. These qualities, along with Dr. Xia’s guidance , will ensure progress on this proposed project.